Mondino was born in Turin and spent most of his early years as a painter in Paris where he worked in William Heyter’s atelier 17, and made mosaics with Gino Severini. In 1960 he moved back to Italy and In 1969 introduced writings and single words into his works, and started experimenting with unusual materials such as sugar and chocolate. During the 1990s Mondino spent a significant amount of time in Morocco, Palestine and Turkey. He exhibited a second time at the Venice Biennale in 1993 (first time in 1976) with a series of large paintings representing whirling dervishes. His first retrospective exhibition was in Florence in 2001.